The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

Cell migration involves the localized extension of actin-rich protrusions, a process that requires Class I phosphoinositide 3-kinases (PI 3-kinases). Both Rac and Ras have been shown to regulate actin polymerization and activate PI 3-kinase. However, the coordination of Rac, Ras and PI 3-kinase acti...

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Pubblicato in:J Cell Sci
Autori principali: Yip, Shu-Chin, El-Sibai, Mirvat, Coniglio, Salvatore J., Mouneimne, Ghassan, Eddy, Robert J., Drees, Beth E., Neilsen, Paul O., Goswami, Sumanta, Symons, Marc, Condeelis, John S., Backer, Jonathan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267689/
https://ncbi.nlm.nih.gov/pubmed/17698922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.005298
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