The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply binding to a glycan mic...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Shewell, Lucy K., Harvey, Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C., Jennings, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267402/
https://ncbi.nlm.nih.gov/pubmed/25422425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412703111
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