All major cholesterol-dependent cytolysins use glycans as cellular receptors

Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptol...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J., Jennings, Michael P.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2020
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244308/
https://ncbi.nlm.nih.gov/pubmed/32494740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4926
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