The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply binding to a glycan mic...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shewell, Lucy K., Harvey, Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C., Jennings, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267402/
https://ncbi.nlm.nih.gov/pubmed/25422425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412703111
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