The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply binding to a glycan mic...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Shewell, Lucy K., Harvey, Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C., Jennings, Michael P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267402/
https://ncbi.nlm.nih.gov/pubmed/25422425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412703111
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