SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Harburg, Gwyndolen, Compton, Jennifer, Liu, Wei, Iwai, Naomi, Zada, Shahrzad, Marlow, Rebecca, Strickland, Phyllis, Zeng, Yi Arial, Hinck, Lindsay
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266005/
https://ncbi.nlm.nih.gov/pubmed/25241737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.007
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