SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Harburg, Gwyndolen, Compton, Jennifer, Liu, Wei, Iwai, Naomi, Zada, Shahrzad, Marlow, Rebecca, Strickland, Phyllis, Zeng, Yi Arial, Hinck, Lindsay
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266005/
https://ncbi.nlm.nih.gov/pubmed/25241737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.007
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