SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Harburg, Gwyndolen, Compton, Jennifer, Liu, Wei, Iwai, Naomi, Zada, Shahrzad, Marlow, Rebecca, Strickland, Phyllis, Zeng, Yi Arial, Hinck, Lindsay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266005/
https://ncbi.nlm.nih.gov/pubmed/25241737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.007
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