SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

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Bibliografiske detaljer
Udgivet i:Stem Cell Reports
Main Authors: Harburg, Gwyndolen, Compton, Jennifer, Liu, Wei, Iwai, Naomi, Zada, Shahrzad, Marlow, Rebecca, Strickland, Phyllis, Zeng, Yi Arial, Hinck, Lindsay
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266005/
https://ncbi.nlm.nih.gov/pubmed/25241737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.007
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