C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

[Image: see text] Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis. Herein we report a novel C5-alkyl-2-methylurea-substituted pyridine series of GK activators derived from our previ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Du, Xiaohui, Hinklin, Ronald J., Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J., Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M., Anderson, Deborah A., Baer, Brian R., Bencsik, Josef R., Boyd, Steven A., Chicarelli, Mark Joseph, Mohr, Peter J., Wang, Bin, Condroski, Kevin R., DeWolf, Walter E., Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D., Medina, Julio C., Coward, Peter, Houze, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265826/
https://ncbi.nlm.nih.gov/pubmed/25516785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500341w
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados