5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

[Image: see text] Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher solubilities than the previously identified triaryl compounds (i.e., AM-2394). Structure–activity relationship studies are pres...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kohn, Todd J., Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E., Kraser, Christopher F., Hinklin, Ronald J., Boys, Mark L., Medina, Julio C., Houze, Jonathan, Dransfield, Paul, Coward, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948010/
https://ncbi.nlm.nih.gov/pubmed/27437074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00145
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