Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

[Image: see text] A direct binding screen of 100 000 sp(3)-rich molecules identified a single diastereomer of a macrolactam core that binds specifically to myeloid cell leukemia 1 (MCL1). A comprehensive toolbox of biophysical methods was applied to validate the original hit and subsequent analogues...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Fang, Chao, D’Souza, Brendan, Thompson, Christopher F., Clifton, Matthew C., Fairman, James W., Fulroth, Ben, Leed, Alison, McCarren, Patrick, Wang, Lili, Wang, Yikai, Feau, Clementine, Kaushik, Virendar K., Palmer, Michelle, Wei, Guo, Golub, Todd R., Hubbard, Brian K., Serrano-Wu, Michael H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265822/
https://ncbi.nlm.nih.gov/pubmed/25516789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500388q
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