Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spontaneously occurring mouse mutation with a loss of...

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Detaylı Bibliyografya
Yayımlandı:Biol Open
Asıl Yazarlar: Siggs, Owen M., Grieve, Adam, Xu, Hongmei, Bambrough, Paul, Christova, Yonka, Freeman, Matthew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265752/
https://ncbi.nlm.nih.gov/pubmed/25395669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.201410116
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