Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spontaneously occurring mouse mutation with a loss of...

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Bibliografiska uppgifter
I publikationen:Biol Open
Huvudupphovsmän: Siggs, Owen M., Grieve, Adam, Xu, Hongmei, Bambrough, Paul, Christova, Yonka, Freeman, Matthew
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265752/
https://ncbi.nlm.nih.gov/pubmed/25395669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.201410116
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