The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair

The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to carcinogenesis, premature aging, and neurodegeneration. Here...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Henriksson, Sofia, Rassoolzadeh, Hanif, Hedström, Elisabeth, Coucoravas, Christos, Julner, Alexander, Goldstein, Michael, Imreh, Gabriela, Zhivotovsky, Boris, Kastan, Michael B., Helleday, Thomas, Farnebo, Marianne
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265676/
https://ncbi.nlm.nih.gov/pubmed/25512560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.246546.114
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