Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks

Altered expression of the multifunctional protein WRAP53β (WD40 encoding RNA Antisense to p53), which targets repair factors to DNA double-strand breaks and factors involved in telomere elongation to Cajal bodies, is linked to carcinogenesis. While loss of WRAP53β function has been shown to disrupt...

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Udgivet i:Cell Death Dis
Main Authors: Rassoolzadeh, H, Böhm, S, Hedström, E, Gad, H, Helleday, T, Henriksson, S, Farnebo, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143398/
https://ncbi.nlm.nih.gov/pubmed/27310875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.172
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