Global Shape and Ligand Binding Efficiency of the HIV-1-neutralizing Antibodies Differ from Those of Antibodies That Cannot Neutralize HIV-1

Asymmetric disposition of Fab arms in the structures solved for the broadly neutralizing monoclonal antibody (nmAb) IgG1 b12 raised the question of whether the unusual shape observed for b12 is common for all IgG1 mAbs or if there is a difference in the overall shape of nmAbs versus non-nmAbs. We co...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Solanki, Ashish K., Rathore, Yogendra S., Badmalia, Maulik D., Dhoke, Reema R., Nath, Samir K., Nihalani, Deepak, Ashish
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Protein Structure and Folding
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263879/
https://ncbi.nlm.nih.gov/pubmed/25331945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563486
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