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Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. The...

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Bibliografische gegevens
Hoofdauteurs: Grossman, W J, Kimata, J T, Wong, F H, Zutter, M, Ley, T J, Ratner, L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1995
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42636/
https://ncbi.nlm.nih.gov/pubmed/7862633
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