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Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model
We have developed a hypoxia-inducible gene therapy approach for the expression of the mature form of human endonuclease G to facilitate cell death in hypoxic regions of the tumor. The chimeric therapeutic gene is placed under the control of a hypoxia response element based promoter and contains a tr...
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| Publicado no: | Cancer Gene Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263319/ https://ncbi.nlm.nih.gov/pubmed/18551145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2008.39 |
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