The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Metabolism and ageing are intimately linked. Compared to ad libitum feeding, dietary restriction (DR) or calorie restriction (CR) consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms(1,2). Similar conditions of nutrient limitation and genetic or pharmacol...

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Publicat a:Nature
Autors principals: Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263271/
https://ncbi.nlm.nih.gov/pubmed/24828042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13264
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