The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Metabolism and ageing are intimately linked. Compared to ad libitum feeding, dietary restriction (DR) or calorie restriction (CR) consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms(1,2). Similar conditions of nutrient limitation and genetic or pharmacol...

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Publicado en:Nature
Autores principales: Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263271/
https://ncbi.nlm.nih.gov/pubmed/24828042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13264
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