The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Metabolism and ageing are intimately linked. Compared to ad libitum feeding, dietary restriction (DR) or calorie restriction (CR) consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms(1,2). Similar conditions of nutrient limitation and genetic or pharmacol...

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Publicado no:Nature
Principais autores: Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263271/
https://ncbi.nlm.nih.gov/pubmed/24828042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13264
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