Investigation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of a Long-Acting α-MSH Analog in Healthy Overweight and Obese Subjects

MC4-NN2-0453 is a novel, long-acting, selective, melanocortin-4-receptor agonist developed for treatment of obesity. This first-human-dose, randomized, double-blind, placebo-controlled trial investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of...

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Udgivet i:J Clin Pharmacol
Main Authors: Royalty, Jane E, Konradsen, Gitte, Eskerod, Ole, Wulff, Birgitte S, Hansen, Birgit S
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Pharmacokinetics/Pharmacodynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263154/
https://ncbi.nlm.nih.gov/pubmed/24166760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.211
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