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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

The opioids are commonly used to treat acute and severe pain. Long-term opioid administration eventually reaches a dose ceiling that is attributable to the rapid onset of analgesic tolerance coupled with the slow development of tolerance to the untoward side effects of respiratory depression, nausea...

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Detalhes bibliográficos
Main Authors: Dumas, Emily O., Pollack, Gary M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628209/
https://ncbi.nlm.nih.gov/pubmed/18989788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9056-1
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