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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective
The opioids are commonly used to treat acute and severe pain. Long-term opioid administration eventually reaches a dose ceiling that is attributable to the rapid onset of analgesic tolerance coupled with the slow development of tolerance to the untoward side effects of respiratory depression, nausea...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628209/ https://ncbi.nlm.nih.gov/pubmed/18989788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9056-1 |
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