Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice

BACKGROUND: Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) leading to the attenuation of leptin rec...

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Bibliographische Detailangaben
Veröffentlicht in:Sleep
Hauptverfasser: Hakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Associated Professional Sleep Societies, LLC 2015
Schlagworte:
Chronic Sleep Fragmentation Induces Hypothalamic Endoplasmic Reticulum Stress
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262953/
https://ncbi.nlm.nih.gov/pubmed/25325461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.4320
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