Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice

BACKGROUND: Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) leading to the attenuation of leptin rec...

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Vydáno v:Sleep
Hlavní autoři: Hakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Associated Professional Sleep Societies, LLC 2015
Témata:
Chronic Sleep Fragmentation Induces Hypothalamic Endoplasmic Reticulum Stress
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262953/
https://ncbi.nlm.nih.gov/pubmed/25325461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.4320
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