Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice

BACKGROUND: Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) leading to the attenuation of leptin rec...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Hakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2015
Assuntos:
Chronic Sleep Fragmentation Induces Hypothalamic Endoplasmic Reticulum Stress
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262953/
https://ncbi.nlm.nih.gov/pubmed/25325461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.4320
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