Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice

BACKGROUND: Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) leading to the attenuation of leptin rec...

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Опубликовано в: :Sleep
Главные авторы: Hakim, Fahed, Wang, Yang, Carreras, Alba, Hirotsu, Camila, Zhang, Jing, Peris, Eduard, Gozal, David
Формат: Artigo
Язык:Inglês
Опубликовано: Associated Professional Sleep Societies, LLC 2015
Предметы:
Chronic Sleep Fragmentation Induces Hypothalamic Endoplasmic Reticulum Stress
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262953/
https://ncbi.nlm.nih.gov/pubmed/25325461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.4320
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