Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase

Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptional role, Strap is localised at mitochondria where...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Maniam, S, Coutts, A S, Stratford, M R, McGouran, J, Kessler, B, La Thangue, N B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262780/
https://ncbi.nlm.nih.gov/pubmed/25168243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.135
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