SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss

Cherubism (OMIM#118400) is a genetic disorder with excessive jawbone resorption caused by mutations in the signaling adaptor protein SH3BP2. Studies on the mouse model for cherubism carrying a P416R knock-in mutation have revealed that mutant SH3BP2 enhances TNF-α production and RANKL-induced osteoc...

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Udgivet i:J Bone Miner Res
Main Authors: Mukai, Tomoyuki, Ishida, Shu, Ishikawa, Remi, Yoshitaka, Teruhito, Kittaka, Mizuho, Gallant, Richard, Lin, Yi-Ling, Rottapel, Robert, Brotto, Marco, Reichenberger, Ernst J., Ueki, Yasuyoshi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262741/
https://ncbi.nlm.nih.gov/pubmed/24916406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2295
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