Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism

Cherubism is caused by mutations in SH3BP2. Studies of cherubism mice showed that TNF-α-dependent autoinflammation is a major cause for the disorder, but failed to explain why human cherubism lesions are restricted to jaws and regress after puberty. We demonstrate that the inflammation in cherubism...

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Detalhes bibliográficos
Main Authors: Yoshitaka, Teruhito, Mukai, Tomoyuki, Kittaka, Mizuho, Alford, Lisa M., Masrani, Salome, Ishida, Shu, Yamaguchi, Ken, Yamada, Motohiko, Mizuno, Noriyoshi, Olsen, Bjorn R., Reichenberger, Ernst J., Ueki, Yasuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177302/
https://ncbi.nlm.nih.gov/pubmed/25220465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.023
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