Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3...

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Bibliographic Details
Published in:Hepatology
Main Authors: Smagris, Eriks, BasuRay, Soumik, Li, John, Huang, Yongcheng, Lai, Ka-man V, Gromada, Jesper, Cohen, Jonathan C, Hobbs, Helen H
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2015
Subjects:
Steatohepatitis/Metabolic Liver Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262735/
https://ncbi.nlm.nih.gov/pubmed/24917523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27242
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