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Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3...
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| Publicado no: | Hepatology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262735/ https://ncbi.nlm.nih.gov/pubmed/24917523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27242 |
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