Multifunctional PEG Retinylamine Conjugate Provides Prolonged Protection against Retinal Degeneration in Mice

[Image: see text] A polyethylene glycol (PEG) retinylamine (Ret-NH(2)) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH(2) to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macul...

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Bibliographische Detailangaben
Veröffentlicht in:Biomacromolecules
Hauptverfasser: Yu, Guanping, Wu, Xueming, Ayat, Nadia, Maeda, Akiko, Gao, Song-Qi, Golczak, Marcin, Palczewski, Krzysztof, Lu, Zheng-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261990/
https://ncbi.nlm.nih.gov/pubmed/25390360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501352s
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