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Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle, increases the susceptibility of mouse retina to acute light-induced photoreceptor degeneration. Abca4(−/−)Rdh8(−/−) mice featuring defective atRAL clearance were used to examine the one or more underlying molecula...

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Detalhes bibliográficos
Main Authors: Chen, Yu, Okano, Kiichiro, Maeda, Tadao, Chauhan, Vishal, Golczak, Marcin, Maeda, Akiko, Palczewski, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281612/
https://ncbi.nlm.nih.gov/pubmed/22184108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315432
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