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Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration
Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle, increases the susceptibility of mouse retina to acute light-induced photoreceptor degeneration. Abca4(−/−)Rdh8(−/−) mice featuring defective atRAL clearance were used to examine the one or more underlying molecula...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281612/ https://ncbi.nlm.nih.gov/pubmed/22184108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315432 |
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