NUTRIENT CHANNELS AND STIRRING ENHANCED THE COMPOSITION AND STIFFNESS OF LARGE CARTILAGE CONSTRUCTS

A significant challenge in cartilage tissue engineering is to successfully culture functional tissues that are sufficiently large to treat osteoarthritic joints. Transport limitations due to nutrient consumption by peripheral cells produce heterogeneous constructs with matrix-deficient centers. Inco...

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Publicado en:J Biomech
Autores principales: Cigan, Alexander D., Nims, Robert J., Albro, Michael B., Vunjak-Novakovic, Gordana, Hung, Clark T., Ateshian, Gerard A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261053/
https://ncbi.nlm.nih.gov/pubmed/25458579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2014.10.017
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