Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions

Zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, produced anti-tumor effects through apoptosis induction or S-phase arrest depending on human mesothelioma cells tested. An addition of isoprenoid, geranylgeraniol but not farnesol, negated these ZOL-induced effects, indicating that the ZOL...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Okamoto, S, Jiang, Y, Kawamura, K, Shingyoji, M, Tada, Y, Sekine, I, Takiguchi, Y, Tatsumi, K, Kobayashi, H, Shimada, H, Hiroshima, K, Tagawa, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260733/
https://ncbi.nlm.nih.gov/pubmed/25393473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.475
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