Zoledronic Acid Produces Combinatory Anti-Tumor Effects with Cisplatin on Mesothelioma by Increasing p53 Expression Levels

We examined anti-tumor effects of zoledronic acid (ZOL), one of the bisphosphonates agents clinically used for preventing loss of bone mass, on human mesothelioma cells bearing the wild-type p53 gene. ZOL-treated cells showed activation of caspase-3/7, -8 and -9, and increased sub-G1 phase fractions...

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Main Authors: Okamoto, Shinya, Jiang, Yuanyuan, Kawamura, Kiyoko, Shingyoji, Masato, Fukamachi, Toshihiko, Tada, Yuji, Takiguchi, Yuichi, Tatsumi, Koichiro, Shimada, Hideaki, Hiroshima, Kenzo, Kobayashi, Hiroshi, Tagawa, Masatoshi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610651/
https://ncbi.nlm.nih.gov/pubmed/23555949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060297
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