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REDD1/DDIT4-independent mTORC1 Inhibition and Apoptosis by Glucocorticoids in Thymocytes

Glucocorticoids (GCs) induce apoptosis in lymphocytes and are commonly used to treat hematologic malignancies. However, they are also associated with significant adverse effects and their molecular mechanism of action is not fully understood. GC treatment induces expression of the mTORC1 inhibitor R...

詳細記述

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書誌詳細
出版年:Mol Cancer Res
主要な著者: Wolff, Nicholas C., McKay, Renée M., Brugarolas, James
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260655/
https://ncbi.nlm.nih.gov/pubmed/24615339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0625
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