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Structural analysis and functional implications of the negative mTORC1 regulator REDD1
REDD1 is a conserved stress-response protein that regulates mTORC1, a critical regulator of cell growth and proliferation that is implicated in cancer. REDD1 is induced by hypoxia and REDD1 overexpression is sufficient to inhibit mTORC1. mTORC1 is regulated by the small GTPase Rheb, which in turn is...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046781/ https://ncbi.nlm.nih.gov/pubmed/20166753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902135e |
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