Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE

A novel cytochrome P450 enzyme TxtE was recently shown to catalyze the direct aromatic nitration of L-tryptophan. This unique chemistry induced us to ask whether TxtE could serve as a platform for engineering new nitration biocatalysts, as a replacement for current harsh synthetic methods. As a firs...

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Bibliographic Details
Published in:Chembiochem
Main Authors: Dodani, Sheel C., Cahn, Jackson K. B., Heinisch, Tillmann, Brinkmann-Chen, Sabine, McIntosh, John A., Arnold, Frances H.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260628/
https://ncbi.nlm.nih.gov/pubmed/25182183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402241
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