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Increased N-Glycosylation Efficiency by Generation of an Aromatic Sequon on N135 of Antithrombin

The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of this N-glycan increases the heparin affinity of the β-glycoform. Recent studies...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Águila, Sonia, Martínez-Martínez, Irene, Dichiara, Gilda, Gutiérrez-Gallego, Ricardo, Navarro-Fernández, José, Vicente, Vicente, Corral, Javier
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259341/
https://ncbi.nlm.nih.gov/pubmed/25485983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114454
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