Increased N-Glycosylation Efficiency by Generation of an Aromatic Sequon on N135 of Antithrombin

The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of this N-glycan increases the heparin affinity of the β-glycoform. Recent studies...

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Udgivet i:PLoS One
Main Authors: Águila, Sonia, Martínez-Martínez, Irene, Dichiara, Gilda, Gutiérrez-Gallego, Ricardo, Navarro-Fernández, José, Vicente, Vicente, Corral, Javier
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259341/
https://ncbi.nlm.nih.gov/pubmed/25485983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114454
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