A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator()

The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionaril...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Uckun, Fatih M., Ma, Hong, Ozer, Zahide, Goodman, Patricia, Zhang, Jian, Qazi, Sanjive
Format: Artigo
Language:Inglês
Published: Elsevier 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259291/
https://ncbi.nlm.nih.gov/pubmed/25506060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2014.10.019
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