Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)–dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceutical composition. This nanoscale liposomal formulat...

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Hlavní autoři: Uckun, Fatih M., Qazi, Sanjive, Cely, Ingrid, Sahin, Kazim, Shahidzadeh, Anoush, Ozercan, Ibrahim, Yin, Qian, Gaynon, Paul, Termuhlen, Amanda, Cheng, Jianjun, Yiv, Seang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663427/
https://ncbi.nlm.nih.gov/pubmed/23568490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-470633
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