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Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Ikaros is a zinc finger-containing DNA-binding protein that plays a pivotal role in immune homeostasis through transcriptional regulation of the earliest stages of lymphocyte ontogeny and differentiation. Functional deficiency of Ikaros has been implicated in the pathogenesis of acute lymphoblastic...

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Main Authors: Uckun, Fatih M., Ma, Hong, Zhang, Jian, Ozer, Zahide, Dovat, Sinisa, Mao, Cheney, Ishkhanian, Rita, Goodman, Patricia, Qazi, Sanjive
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497833/
https://ncbi.nlm.nih.gov/pubmed/23071339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209828109
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