KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION

Ikaros (IK) malfunction has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL), the most common form of childhood cancer. Therefore, a stringent regulation of IK activity is very important. Here we provide unique genetic and biochemical evidence that the Ku protein components...

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Bibliographic Details
Main Authors: Ozer, Zahide, Qazi, Sanjive, Ishkhanian, Rita, Hasty, Paul, Ma, Hong, Uckun, Fatih M.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902664/
https://ncbi.nlm.nih.gov/pubmed/24478815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5376/ijmms.2013.03.0007
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