POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITION COUNTERACTS MULTIPLE MANIFESTATIONS OF KIDNEY DISEASE IN LONG-TERM STREPTOZOTOCIN-DIABETIC RAT MODEL

Evidence for the important role for poly(ADP-ribose) polymerase (PARP) in the pathogenesis of diabetic nephropathy is emerging. We previously reported that PARP inhibitors counteract early Type 1 diabetic nephropathy. This study evaluated the role for PARP in kidney disease in long-term Type 1 diabe...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Shevalye, Hanna, Stavniichuk, Roman, Xu, Weizheng, Zhang, Jie, Lupachyk, Sergey, Maksimchyk, Yury, Drel, Viktor R., Floyd, Elizabeth Z., Slusher, Barbara, Obrosova, Irina G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259265/
https://ncbi.nlm.nih.gov/pubmed/19945439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.11.018
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