Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma

Malignant melanoma is associated with poor clinical prognosis; however, novel molecular and immune therapies are now improving patient outcomes. Almost 50% of melanomas harbor targetable activating mutations of BRAF which promote RAS-RAF-MEK-ERK pathway activation and melanoma proliferation. Recent...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Ilieva, Kristina M., Correa, Isabel, Josephs, Debra H., Karagiannis, Panagiotis, Egbuniwe, Isioma U., Cafferkey, Michiala J., Spicer, James F., Harries, Mark, Nestle, Frank O., Lacy, Katie E., Karagiannis, Sophia N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258403/
https://ncbi.nlm.nih.gov/pubmed/25385327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0290
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