IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin

B cells participate in immune surveillance in human circulation and tissues, including tumors such as melanoma. By contrast, the role of humoral responses in cutaneous immunity is underappreciated. We report circulating skin-homing CD22+CLA+B cells in healthy volunteers and melanoma patients (n = 73...

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Publicado no:Sci Rep
Main Authors: Saul, Louise, Ilieva, Kristina M., Bax, Heather J., Karagiannis, Panagiotis, Correa, Isabel, Rodriguez-Hernandez, Irene, Josephs, Debra H., Tosi, Isabella, Egbuniwe, Isioma U., Lombardi, Sara, Crescioli, Silvia, Hobbs, Carl, Villanova, Federica, Cheung, Anthony, Geh, Jenny L. C., Healy, Ciaran, Harries, Mark, Sanz-Moreno, Victoria, Fear, David J., Spicer, James F., Lacy, Katie E., Nestle, Frank O., Karagiannis, Sophia N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944184/
https://ncbi.nlm.nih.gov/pubmed/27411958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29736
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