IgG4 subclass antibodies impair antitumor immunity in melanoma

Host-induced antibodies and their contributions to cancer inflammation are largely unexplored. IgG4 subclass antibodies are present in IL-10–driven Th2 immune responses in some inflammatory conditions. Since Th2-biased inflammation is a hallmark of tumor microenvironments, we investigated the presen...

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Detalhes bibliográficos
Main Authors: Karagiannis, Panagiotis, Gilbert, Amy E., Josephs, Debra H., Ali, Niwa, Dodev, Tihomir, Saul, Louise, Correa, Isabel, Roberts, Luke, Beddowes, Emma, Koers, Alexander, Hobbs, Carl, Ferreira, Silvia, Geh, Jenny L.C., Healy, Ciaran, Harries, Mark, Acland, Katharine M., Blower, Philip J., Mitchell, Tracey, Fear, David J., Spicer, James F., Lacy, Katie E., Nestle, Frank O., Karagiannis, Sophia N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613918/
https://ncbi.nlm.nih.gov/pubmed/23454746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65579
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