Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma

Malignant melanoma is associated with poor clinical prognosis; however, novel molecular and immune therapies are now improving patient outcomes. Almost 50% of melanomas harbor targetable activating mutations of BRAF which promote RAS-RAF-MEK-ERK pathway activation and melanoma proliferation. Recent...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Ilieva, Kristina M., Correa, Isabel, Josephs, Debra H., Karagiannis, Panagiotis, Egbuniwe, Isioma U., Cafferkey, Michiala J., Spicer, James F., Harries, Mark, Nestle, Frank O., Lacy, Katie E., Karagiannis, Sophia N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258403/
https://ncbi.nlm.nih.gov/pubmed/25385327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0290
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