SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs

LIN28 mediated processing of the miRNA let-7 has emerged as a multi-level program that control self-renewal in embryonic stem cells. LIN28A is believed to primarily act in the cytoplasm together with TUT4/7 to prevent final maturation of let-7 by Dicer, whereas LIN28B has been suggested to preferent...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Kim, Seung-Kyoon, Lee, Hosuk, Han, Kyumin, Kim, Sang Cheol, Choi, Yoonjung, Park, Sang-Wook, Bak, Geunu, Lee, Younghoon, Choi, Jung Kyoon, Kim, Tae-Kyung, Han, Yong-Mahn, Lee, Daeyoup
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258232/
https://ncbi.nlm.nih.gov/pubmed/25479749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.10.016
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